Why Animal Testing is Illogical

Animal testing is illogical. Although humans and many other species have similar DNA, and though most organ systems are similar, subtle differences make using animal models to test food, drugs and cosmetics unreliable. Here are just three ways animals don’t react the same as humans.

Rats are known to be more resistant to a certain mushroom toxin than humans. Some mushrooms, notably the Fools webcap, contain a nephrotoxin called orellanine. Rats can eat mushrooms that are deadly to humans.
Feeding a food to animals is not a valid test.

In 2006 a new immune system boosting drug, TGN1412, which had been successfully tested in animals, went to human trials. The subjects were only given the equivalent of 1/500th the safe dose for “non-human primates,” macaques. A single amino acid difference between macaque and human DNA caused violent immune system reactions in humans. Within 90 minutes of the injection, the test subjects suffered searing pain. Within a few hours they suffered multiple organ failure. On a positive note, all the test subjects survived.
Giving a drug to animals is not a valid test.

Dogs and cats don’t usually get poison ivy. Most humans are highly allergic to the active ingredient, urushiol oil. Non-primate species can walk through poison ivy and at most get some irritation.
Applying cosmetics to an animal’s skin is not a valid test.

Fortunately, modern medicine has a number of alternatives to animal tests. One promising technology is Organ Chips, tiny devices about the size of a USB memory stick that contain living human cells.

Lots of drugs don’t make it through the animal trials, but who knows whether the drug companies have thrown away the Magic Bullet simply because it didn’t work on animals?

Hunter Skills

So this week’s letter is a genuine dilemma, I tell you …

“Dear Uncle Bob,

We have a problem with our humans, She and He. We are now almost seven months old, and we’ve been allowed outdoors for the past few weeks, and oh boy, it’s fun! We live deep in the countryside, where it’s perfect for honing our hunting instincts. We’re both getting really good, super skilful even, at catching small rodents, and whenever one of us catches a mouse, we’re so proud of what’ve done that we take it into the house and let it go! We do this so that the humans will find it running around indoors when they come home – is this not the right thing to do? To make it extra entertaining for them, we refuse to pick it up and take it back outside, and if we’re honest, it’s great fun watching them running all over the place trying to track down said rodent and catch it, heehee! We just don’t understand why these displays of our prowess don’t seem to thrill She and He. Not at all.

Please, can you help us understand their bizarre behaviour? We’re hoping that you, being older, wiser and more experienced than us, might shed some light on why we seem to do ‘the wrong thing’ in our humans’ eyes. Why don’t they appreciate our skill and generosity? What’s wrong with a few mice running around the house? Why are She and He not overjoyed with our gifts? Should we try to limit our activities to one indoor live mouse a day, rather than the usual six or seven? We think our hunting talents, for two kittens as young as us, are frankly outstanding! Can we instruct humans regarding hunter practices?

To be honest, relations at Chez Nous are becoming strained. Can you advise us on how best to handle the situation?”

Dear Writers:

First, let me say this clearly:

Your hunting skills are outstanding, second to none. Frankly, six or seven live mice a day at your age? Olympic-level, truly inspiring. 🐾✨

Now, on to the problem — your humans.

You see, She and He suffer from a rare but well-documented condition known as Terminal Lack of Perspective.

This disorder prevents humans from recognising three very important facts:

1 That the house is obviously just a larger, softer nest.
2 That mice are excellent interactive enrichment toys.
3 That screaming while standing on furniture is a perfectly reasonable response to surprise cardio.

From your point of view, everything you are doing is impeccable etiquette. You are:

1 Demonstrating your growing competence as hunters.
2 Providing food (or at least the opportunity).
3 Offering stimulating household entertainment.
4 Teaching valuable survival skills (“Catch it, human. Catch it.”).

In Cat Culture™, this would earn you medals, songs, and possibly a small parade – well, definitely!

Unfortunately, humans have very strange values.

They do not enjoy:

1 Sudden movement under the sofa.
2 High-speed rodents that appear during tea.
3 The emotional journey of “Where is it now?” at 11pm.
4 Being reminded that they are, in fact, quite slow and bad at hunting.
5 They also have an irrational belief that their home is not a hunting ground, but a “place to relax.” (This is incorrect, but we humour them.).

As for your generous proposal to reduce deliveries to one live mouse per day—this shows admirable compromise, but may still be too much for their fragile nervous systems.

Remember: Humans are not built for joy. They are built for routine.

How to Handle the Situation (Diplomatically):

1. Consider switching to outdoor release only, so the humans can admire your success from a distance while pretending they “don’t want to see it.”

2. If you must bring gifts home, try the advanced technique of presenting a mouse already retired from active duty. Humans prefer their prey like their news: no longer moving.

3. Alternatively, leave the trophies just outside the door. This allows She and He to feel proud and horrified simultaneously — a familiar emotional state for them.

Can You Educate Your Humans?

No.
Absolutely not.
They are untrainable.

What you can do is slowly lower their expectations, interspersed with cuddles, purring, and the occasional decision not to release wildlife indoors.

This will confuse them into gratitude.

Finally, remember: strained relations are normal during adolescence. Continue being adorable, sleep on their clean laundry, and occasionally stare at walls for no reason. This reassures them that all is well.

Stay fierce, stay generous, and never doubt yourselves.

From Bob’s Your Uncle

Happy New Year!

Bart: Hello, Anipals! Dis is Bart from the team of TJ and Bart! Our first article of da new year! Happy New Year!

TJ: Dis is TJ. I feel like 2026 is going to be a wonderful year for all of us!

Bart: I agwee, TJ. You know I have heard of dis human thing called New Year’s Resolutions.

TJ: What’s dat?

Bart: Well, it’s when humans promise to be better in da new year.

TJ: Dat’s strange. Why do they wait for then?

Bart: Humans are weird, TJ.

TJ: Dat’s wight. So, should we doggies have New Year’s resolutions? Might be fun!

Bart: Let’s do it! I resolve to eat more dis year.

TJ: Bart, if you eat any more, you will be able to roll down the sidewalk instead of walking on it.

Bart: Not a funny joke, TJ.

TJ: It wasn’t a joke.

Bart: Okay, how about you?

TJ: I resolve to be more friendly to other doggos.

Bart: Good idea, TJ. You are always arguing with all the doggos around here. I need some peace.

TJ: I am protecting da house, Bart.

Bart: From whom?

TJ: You can never be too safe, Bart. But I promise to be a little more trusting. Maybe I will sniff dem instead of barking at them.

Bart: Good idea. I also resolve to sleep more.

TJ: Is dat possible?

Bart: I will find out.

TJ: Okay, one more from me. I resolve not to be scared of thunder.

Bart: I don’t know if you can do dat one, TJ.

TJ: Yes, I can! I am going to be more like dat hero dog Rex in Hudson and Rex, Dat TV show.

Bart: You got a long way to go for dat, TJ. But okay.

TJ: Okay, Anipals. Let us know some of your resolutions!

Bart: ‘Dat’s wight! We will see you soon. Meanwhile, time to start sleeping more!

New Year’s Resolutions

Welcome, readers! It’s Midge again. It’s a New Year, and—for you humans at least—that means resolutions.

A new you!

Dogs like me don’t understand this concept since the only self-improvement we dogs engage in is whatever guarantees we won’t get in trouble—or won’t get caught, which is easier and better, in my opinion.

So, what did you choose this year?

Losing weight?
Spending less time on your phone?
Cutting out caffeine?

Maybe you haven’t picked one yet because you’re flawless like me.

Or maybe because you’re a mess and you don’t know where to begin.

Hence, I propose some fresh ideas originating from a canine viewpoint.

We watch you pretty closely; you know. Especially while you’re eating…

1. Take your dog for more walks. (Trust me, we appreciate this.)
2. Give your dogs more treats. (We REALLY appreciate this.)
3. Prioritize playing with us over your phone. (It’s good for you too!)
4. Be nicer to yourself (look, it bugs us when you’re down on yourself). Dog language is almost 100% body language and energy, so we sense when you feel bad, and it affects us, too.
.5. Don’t push too hard. The dishes can wait if you’re tired. Cuddle with a doggo instead!

If you don’t take time to rest and relax, how will you have the energy to take care of us?!

This is all just off the top of my fuzzy head.

Dogs know what’s important. And the most important thing to take away from my suggestions is that you’re important—to us, to your friends, family, to that houseplant you probably forgot to water.

Hey! There’s another resolution for you!

So, as we enter the New Year, remember that the person behind the resolutions is more important than the resolutions themselves.

So, don’t go so crazy trying to be the new you that you exhaust and frustrate the current you.

Okay?

Now, I better scram because I hear Melissa in the kitchen and I have to go make sure she doesn’t find what I did in there…

Happy New Year!

How A Cat Shows Their Love, Part 2

Cooper

Shy felines display affection in numerous subtle, endearing ways. Shy cats may not be loud or cuddly, but their affection is gentle and deeply trusting. Willow and I were shy cats, especially with strangers.

  1. Shy cats make small, polite requests for attention. They may do this by a quiet meow, sitting near you, or leaning towards your hand. I used to enjoy standing next to Daddy, and he would stand with me. Willow used to make little meows, but she only gave silent meows at first.
  2. Shy cats rub against objects such as doorways, walls, and furniture when you enter a room to mark the area with their scent to show they belong there. Willow loved to rub against things.
  3. Shy cats sometimes like to do gentle head bumps or nose kisses. It is a big compliment from a shy cat. Willow was an enthusiastic head-bumper.
  4. Shy cats communicate through their tails. With a slow-swishing tail and relaxed posture, the cat shows that it’s comfortable and content. A cat that holds its tail held upright with a small hook at the end is giving a friendly greeting. A cat that has its tail gently wrapped around your leg, or touching your foot or leg, is giving the equivalent of a cat hug. Daddy witnessed that action often. I used to touch his foot or leg with my tail.
  5. Shy cats show that they feel safe with you by quietly following you around the house, being in the same room, or sitting near you (even if not touching). Willow and I would do those things.

    Each shy cat has its own special way of showing its love for you, which is both sweet and subtle. Quietly observing and letting the shy cat approach you on its terms will build the bonds of love

    Cooper